Combined Agonist-Antagonist Treatment for Nicotine and Other Drug Dependencies
نویسندگان
چکیده
منابع مشابه
The neurobiological basis for partial agonist treatment of nicotine dependence.
Smoking cessation has major health benefits for men and women of all ages. However, most smokers are addicted to nicotine and fail repeatedly in their attempts to quit. Stimulation of nicotinic receptors in the brain, particularly alpha4beta2 receptors, releases dopamine in the meso-limbic area of the brain and is reinforcing. Nicotine abstinence reduces dopamine release, and this is associated...
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Over the last decade there have been significant advances in the discovery and understanding of the cannabinoid system along with the development of pharmacologic tools that modulate its function. Characterization of the crosstalk between nicotine addiction and the cannabinoid system may have significant implications on our understanding of the neurobiological mechanisms underlying nicotine dep...
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Microbiologic investigation of the prevention of emergence of mutant populations of tubercle bacilli resistant to streptomycin and isoniazid emphasized the fact that adequate concentrations of each of these two appropriate drugs were necessary (1). Delivery of such concentrations of isoniazid to the multiplying parasites can be estimated by microbiologic assay (2-4). Antimicrobially-active seru...
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چکیده ندارد.
15 صفحه اولMecamylamine (a nicotine antagonist) for smoking cessation.
BACKGROUND Mecamylamine is a nicotine antagonist (that is it blocks the effect of nicotine). The rationale for its use in smoking cessation is that it may block the rewarding effect of nicotine and thus reduce the urge to smoke. OBJECTIVES The objective of this review was to determine the effectiveness of mecamylamine in promoting smoking cessation, either alone or in combination with nicotin...
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ژورنال
عنوان ژورنال: Neuropsychopharmacology
سال: 1994
ISSN: 0893-133X,1740-634X
DOI: 10.1038/sj.npp.1380199